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Dose-dependent cytotoxic effect of ZnO/CS/CAZ/MTF nanocomposite <t>on</t> <t>WI-38</t> lung fibroblast cells determined via MTT assay
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Dose-dependent cytotoxic effect of ZnO/CS/CAZ/MTF nanocomposite on WI-38 lung fibroblast cells determined via MTT assay

Journal: Microbial Cell Factories

Article Title: A novel green synthesized ZnO-based antimicrobial nanocomposite: synergistic action, in vitro cytotoxicity, and molecular docking studies of ceftazidime, metformin, and chitosan against multidrug-resistant Salmonella enterica

doi: 10.1186/s12934-026-02934-x

Figure Lengend Snippet: Dose-dependent cytotoxic effect of ZnO/CS/CAZ/MTF nanocomposite on WI-38 lung fibroblast cells determined via MTT assay

Article Snippet: The human lung fibroblast cell line (WI-38) was obtained from ATCC through the Holding company for biological products and vaccines (VACSERA) in Cairo, Egypt.

Techniques: MTT Assay

Biocompatibility of anti-PLT LNPs. Light microscopy images of human fibroblasts cultured for 24 h with anti-PLT LNPs mixed with a growth medium at ratios of 0:1 (control), 0.5:1 (9.60 ± 0.09 × 10 −3 mol NO exposure), and 1:1 (19.20 ± 3.68 × 10 −3 mol NO exposure) show that cell population density in the 0.5:1 group was comparable to that in the control group. In contrast, a reduction in cell density was observed at the 1:1 ratio, consistent with the known antiproliferative effects of higher NO concentrations.

Journal: Frontiers in Medical Technology

Article Title: Drug-loaded nanoparticles reduced platelet aggregation and blood coagulation

doi: 10.3389/fmedt.2025.1690389

Figure Lengend Snippet: Biocompatibility of anti-PLT LNPs. Light microscopy images of human fibroblasts cultured for 24 h with anti-PLT LNPs mixed with a growth medium at ratios of 0:1 (control), 0.5:1 (9.60 ± 0.09 × 10 −3 mol NO exposure), and 1:1 (19.20 ± 3.68 × 10 −3 mol NO exposure) show that cell population density in the 0.5:1 group was comparable to that in the control group. In contrast, a reduction in cell density was observed at the 1:1 ratio, consistent with the known antiproliferative effects of higher NO concentrations.

Article Snippet: The WI-38 human lung fibroblast cell line was purchased from ATCC (Manassas, VA, USA).

Techniques: Light Microscopy, Cell Culture, Control